Hydrophilic polymers containing chiral nucleic acid base pendants as polynucleotide analogs
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چکیده
منابع مشابه
Hydrophilic Polymers Containing Chiral Nucleic Acid Base Pendants as Polynucleotide Analogs
A survey of our recent work on synthetic polynucleotide analogs is given. Propionic acid and 3-methyl butyric acid derivatives substituted in the 2-position with nucleic acid bases have been used as chiral pendants for attachment to hydrophilic polyamine backbones. Hindered rotation about the amide bonds formed promotes a base-stacked structure as shown by ultraviolet hypochromic effects versus...
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Nucleic acids contain severa' characteristic structural features: a chiral center adjacent to the base, a stereoregular, hydrophilic poly(phosphate-ribose) backbone which is negatively charged at neutral pH, and a helical secondary structure arising from conformational preferences enforced by base-stacking. We have prepared and studied several synthetic polynucleotide analogs having linear poly...
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We present the first nucleobase analog fluorescence resonance energy transfer (FRET)-pair. The pair consists of tC(O), 1,3-diaza-2-oxophenoxazine, as an energy donor and the newly developed tC(nitro), 7-nitro-1,3-diaza-2-oxophenothiazine, as an energy acceptor. The FRET-pair successfully monitors distances covering up to more than one turn of the DNA duplex. Importantly, we show that the rigid ...
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ژورنال
عنوان ژورنال: Polymer Bulletin
سال: 1981
ISSN: 0170-0839,1436-2449
DOI: 10.1007/bf00254354